It can be said that the application of mathematical methods played a great role in promoting the initial scientific revolution. The mathematical law of planetary motion summarized by Kepler or the mathematical expression of motion put forward by Galileo are milestones in the history of modern scientific development. With the application of mathematical methods in natural science, mathematics itself has made new progress. Leibniz and Newton invented calculus respectively, and these methods were quickly mastered by scientists at that time and became their tools for scientific research.

Whether it is natural science or humanities, its knowledge building is gradually built by countless people, but some people add revolutionary bricks and tiles through the next level, while others just add bricks and tiles as an intermediate link. In the process of understanding, human beings have to go through many ideological repetitions, comparisons, hesitations, temptations and guesses; Even in the wrong cognitive model, there may be positive factors. Galen's description of circulatory system has such special significance. It was by discovering the mistakes in his works that people in the Renaissance formed a new concept of blood flow.