Pathogen infection is the main pathogenic factor. Because the body's resistance is low, bacteria or other virulent pathogens grow rapidly and multiply after infecting the prostate, mostly blood-borne infection and transurethral retrograde infection. The main pathogenic bacteria are Escherichia coli, followed by Staphylococcus aureus, Klebsiella pneumoniae, Proteus, Pseudomonas and so on. Most of them are infected by a single pathogen.

Type Ⅱ prostatitis

The main pathogenic factor is pathogen infection, but the organism has strong resistance or/and weak virulence to pathogens, with retrograde infection as the main pathogen, Staphylococcus as the main pathogen, followed by Escherichia coli, Corynebacterium and Enterococcus. Prostatic calculus and urine reflux may be the important reasons for the persistence of pathogens and the recurrence of infection.

Type Ⅲ prostatitis

The pathogenesis is unknown, the etiology is very complicated and controversial: it may be caused by an initial factor or by multiple factors from the beginning, one or more of which plays a key role and influences each other; It may also be that many different diseases are difficult to identify, but their clinical manifestations are the same or similar; Even though these diseases have been cured, the damage and pathological changes they caused continue to play an independent role. Most scholars believe that the main reasons may be pathogen infection, inflammation, abnormal pelvic floor neuromuscular activity and immune abnormality.