Pharmacokinetics is a relatively young frontier science between pharmacy and mathematics, and it is a new field of pharmacy that has developed rapidly in recent 20 years. Pharmacokinetics is a science to study the changes of drug content in animals with time, and it is a kind of pharmacology.
Pharmacokinetics, also known as pharmacokinetics, quantitatively describes and summarizes the absorption, distribution, metabolism and excretion of drugs through various channels (such as intravenous injection, intravenous drip, oral administration, etc.) by applying kinetic principles and mathematical models. ).
That is, the dynamic law (ADME) of "dose-time" change or "blood drug concentration-time" change during absorption, distribution, metabolism and excretion. Pharmacokinetics studies the relationship between the level and time of drug metabolites in various body fluids, tissues and excreta, and studies the mathematical relationship needed to explain these data models.
Pharmacokinetics has become the most important and close foundation of biopharmaceutics, pharmacology, toxicology and other disciplines, which has promoted the vigorous development of these disciplines. It is also closely related to basic disciplines such as mathematics, chemical kinetics and analytical chemistry. It has developed rapidly in recent 20 years, and its research results are helpful to guide the design of new drugs, optimize dosage forms and improve dosage forms.