The square of 2x times x is the cube of 2x. X times the square of negative X is the third power of X, (the square of negative X) is the square of negative X, multiplied by the square of X is the fourth power of negative X, and finally 16 is added. After simplification, it is like this:

2x3-x 3-x 4 + 16

The fourth power of = .3 x+16.

The smallest prime number is 2, take it in, the third power of 2 MINUS the fourth power of 2, and finally add 16. It shouldn't be difficult to do it yourself.