Guangzhou No.41 Middle School was founded in 1958. It was a junior high school in the early days. 1969 opened a high school with the approval of the superior and became a complete middle school. Through the joint efforts of all teachers and students for decades, the school has developed by leaps and bounds from ordinary middle schools to municipal schools and then to provincial schools, from 1999 to 2003.

In order to adapt to the development of the new situation and meet the people's demand for quality education, according to the plan of Haizhu District Education Bureau to adjust the school layout, it merged with Shayuan Middle School in September 2003, and the school has formed a scale with two campuses as the core.

The school belongs to the Education Bureau of Haizhu District, Guangzhou. It is a first-class school in Guangdong Province, a "modern technology experimental school" and a "green school" in Guangdong Province. The campus covers an area of 25,000 square meters with a building area of 23,000 square meters.

The quality of education and teaching in the school has been significantly improved, and it won the first prize for the work of senior three graduating classes in Guangzhou for six consecutive years. In 2004, the online rate of undergraduate students exceeded 6 1%, and the online rate was 100%.