What areas of our lives will use biological knowledge? What's the new progress in biology? The latest development of computational biology.
Author: Source: Shanghai Branch Publisher: Liu Bin Category: News Scan Date: August 3, 20051Today/General View: August 6352.
The 60th academic seminar of Oriental Science and Technology Forum was held in Shanghai Huxing Science and Technology Library on July 2-3, 2005. This forum is jointly organized by Shanghai Bioinformatics Research Center and School of Life Sciences of Fudan University. The theme of the forum is "the latest progress in computational biology". Researcher of Shanghai Institute of Life Sciences of China Academy of Sciences and Professor Zong of Department of Computing Science of National University of Singapore co-chaired the meeting.
I. Background of the meeting
With the implementation and deepening of the human genome project, the accumulation of biological data has made an unprecedented leap. Not only does the amount of data increase exponentially, but the nature of data has jumped from physiological and biochemical data to genetic information, and further jumped to the information of the relationship between heredity and structure and function. This rapid and massive accumulation of scientific data is unprecedented in the history of human scientific research. How to extract useful knowledge from these massive biological data has become a great challenge for biologists, mathematicians and computer experts. This leads to a new discipline: computational biology. Computational biology refers to the development and application of data analysis and theoretical methods, mathematical modeling and computer simulation techniques used in biological research. Computational biology is becoming one of the core methods of modern biological research. Their importance and complexity are becoming more and more obvious in more and more biological data. The more complex the question to be answered, the more prominent it is, making computational biology one of the most dynamic emerging frontier disciplines in life science. Computational biology uses large-scale and efficient theoretical models and numerical calculations to identify the coding region representing protein in the genome sequence and decipher the genetic language rules hidden in the nucleic acid sequence; Predict the three-dimensional structure and dynamic characteristics of protein directly from protein sequence, study the relationship between the structure and function of biomacromolecules, the interaction between biomacromolecules and the interaction between biomacromolecules and ligands, and promote the development of protein engineering, protein design and computer-aided drug design; At the same time, the transcription spectrum and protein spectrum data related to the information release and regulation of genomic genetic language are summarized and sorted out to simulate the information flow process in life, so as to understand the laws of metabolism, development, differentiation and evolution, make it possible to explore all aspects of human health and diseases from a new perspective of genome science, and transform the success of human genome project into progress in the medical field.
Using computational biology, scientists are expected to determine the role of genes and pathways in health and disease, and explore their relationship with environmental factors; Develop, evaluate and apply genome-based diagnostic methods to predict susceptibility to diseases, drug responses, early diagnostic markers of diseases, and the development mechanism of diseases at the molecular level; Using the knowledge of genome and metabolic pathway, computer-aided drug design is carried out through molecular simulation and other methods to shorten the development cycle of new drugs, thus developing effective new disease treatment methods; Develop genome-based tools to improve public health, so as to promote the human genome project to benefit mankind.
At present, computational biology is highly valued internationally. The National Institutes of Health (NIH) is the most important research institution engaged in life science research in the world, and its annual budget accounts for about 60% of scientific research investment in the United States. With the completion of the human genome project and the advent of the post-genome era, NIH formed a "medium and long-term development plan" leading to the future of life science in 2003 after a series of discussions with more than 300 biomedical authorities from American academic institutions, departments and private organizations. In the NIH roadmap, the project "Bioinformatics and Computational Biology" was launched, hoping to pave an "information superhighway" leading to the future of life science through the implementation of this project. The project plans to establish several "national biomedical computing centers" from 2004 to develop related software and data management tools. In 2003, the head of the National Human Genome Research Institute (NHGRI) under the National Institutes of Health (NIH) published an article entitled "The Prospect of Genomics Research" in Nature. The prospect of genome research described in this article comes from hundreds of scientists and the public, and more than a dozen seminars and countless discussions with individuals have been held. After nearly two years of intense discussion. In this paper, the prospect of genome research is divided into three themes and six sections. These three themes are: genomics and biology, genomics and health, genomics and society; These six parts are: resources, technological development, computational biology, training, ethics, legal and social application and education. Six important cross sections are related to all three topics, and computational biology is an important part of them.
In China, the National Natural Science Foundation of China regards computational biology as one of the key research directions. Shanghai, which pays attention to the development of biomedical industry and high-tech industry, attaches great importance to computational biology research. In 2002, the computational biology laboratory jointly established by Shanghai Institute of Pharmacology of China Academy of Sciences and SGI Computer Company of the United States was inaugurated in Shanghai Institute of Pharmacology. The Chinese Academy of Sciences cooperates with Max Planck Institute, the largest research institution in Germany, and plans to cooperate in computational biology research in Shanghai. In June, 2004, the preparatory meeting for the establishment of Institute of Computational Biology was held in Shanghai Institute of Life Sciences, China Academy of Sciences. IBM is the only company in the world that can apply its professional research technology to computational biology and parallel computing. In 2002, IBM established a high-performance biological science research laboratory together with Shanghai Bioinformatics Technology Research Center and InforSense Company in the UK, and cooperated in the research and development of computational biology. Therefore, holding a symposium on computational biology in Shanghai will promote the better development of computational biology in our city and even the whole country, and play a positive role in promoting the development of biomedical industry in our city.
Because molecular simulation and computer-aided drug design are hot issues in computational biology at present, and the direction of the closest combination of computational biology and biomedical industry, the progress made in computational biology will directly promote the development of biomedical industry. Therefore, this conference will focus on the development and future direction of biomacromolecule computational simulation, computer-aided drug design and computational biology.
Where will you use directional knowledge in your life? 1, when you go somewhere to see the map.
2. When you get lost
3. When driving
4. When telling others the location,
Look at the orientation of the house. Install a satellite antenna. Some people look at Feng Shui, maps and constellations.
(1) orienteering. This is a sport that uses maps and compasses to navigate. It is attracting more and more people to participate in it and is crazy about it all over the world. It is not only an outdoor recreational sport, but also a competitive sport. Taking part in orienteering requires not only a compass and a map, but also special equipment. It is a relatively economical sport.
(2) When you get lost, you will also use the knowledge of direction.
I like thousands of tons of biological knowledge in life. Good mask, good breathability and faint fragrance. I bought it at Tmall flagship store.
What field of life is a big concept, and there is no authoritative definition and division at present, because there is no need to use the word "field" only when necessary. After a certain discipline is classified, the corresponding part is called a certain field. It can also be called an advanced field.
According to this concept, we can divide the big life field concept into countless small life fields, such as:
By nature, we have family life, marriage life, leisure life, religious life, political life, organizational life, study life, including work field, which should also be included in the big concept of life field;
It can be divided into public life and private life according to the scope;
According to age, it can be divided into children's life, children's life, teenagers' life, old people's life and other fields.
It can also be divided by gender, with male-only and female-only living areas, such as female-only beauty SPA and so on;
The division of these fields can enable the society to provide targeted services, thus improving the overall quality of life and bringing business opportunities.
The above are personal opinions and are for reference only.
What books about chemistry are there in life? The textbook is
Where will you use coding knowledge in your life? For example, this page now.