Competitive inhibition means that when the structure of inhibitors is similar to that of substrate, they compete for the active site of the same binding site of enzyme, which hinders the combination of substrate and enzyme and leads to the decrease of catalytic reaction rate of enzyme. This kind of inhibition is called competitive inhibition. Competitive inhibitors usually compete with normal substrates or ligands for the same protein binding site. Inhibitors compete with substrates for the active sites of enzymes. When the inhibitor binds to the active site of the enzyme, the substrate can no longer bind to the enzyme, and vice versa.

Mechanism of competitive inhibition:

1, the structure of inhibitor and substrate is similar.

2. It may bind to the site of substrate binding (such as binding group), thus blocking the binding between substrate and enzyme.

3. Reduce the affinity between enzyme and substrate.