1844, Bernard first inserted a catheter into the heart of an animal. From 65438 to 0929, German doctor forssman first inserted a catheter from his elbow vein and sent it to the right atrium through the superior vena cava, and took the first chest radiograph of cardiac catheter in medical history, which initiated the development of human cardiac catheter technology. On this basis, right cardiac catheterization and left cardiac catheterization were performed successively. 1953, seldinger founded the percutaneous vascular puncture technique, thus ending the history of interventional surgery requiring vascular incision. 1958, Sones accidentally inserted a catheter into the right coronary artery during an aortography, and injected a contrast agent, which was right coronary angiography. This accidental and dangerous event became the beginning of modern coronary intervention technology. From 65438 to 0967, Judkins performed coronary angiography through femoral artery puncture, which was further developed and popularized in the diagnosis of coronary heart disease. Gruentzig of Germany first performed percutaneous coronary angioplasty in 1977. Since then, PTCA technology has spread rapidly from Europe to America, and its indications have been expanding. Related industrial products have also developed rapidly, and various surgical equipment (such as catheters and balloons) have been continuously improved to adapt to the treatment of different lesions. From 65438 to 0986, Puol and Sigmart implanted the first coronary stent into human body. Coronary stent implantation can significantly reduce restenosis of PTCA, and can deal with dissection and acute vascular occlusion, which has become another milestone in coronary intervention. In 2003, drug-eluting stents (DES) were put into clinical use, which significantly reduced the restenosis rate of stents and brought coronary intervention into a new era.