Let's assume that the original bottle of juice is x ml, so half of the juice is x/2.

For the first time, if you drink half of all the juice, less than 50 ml is: x/2-50 = (x-100)/2;

Note: Now the remaining juice in the bottle is: (x/2)+50 = (x+ 100)/2.

Then the remaining half of the juice is: ((x+100)/2)/2 = (x+100)/4.

I drank more than half of the juice for the second time, and 25ml was: (x+ 100)/4+25 = (x+200)/4.

At this time, there is 125ml: 125 left in the bottle.

So how many milliliters should this bottle of juice have = remaining+second cup+first cup:

x = 125+((x+200)/4)+((x- 100)/2)

By solving this formula, the value of x can be calculated: 500.

So the answer is 500 ml.