Two boxes of medicine, one ***52 yuan and one box of 26 yuan, grandma gave her 100 yuan, and the clerk gave it to grandma 48 yuan.

After I found the change, I calculated it with decimal addition and subtraction. Grandma can also pay like this: 1. Give it to 50 yuan, the shop assistant, and then give it to 10 yuan for 8 yuan. If grandma has change, she can pay 5 pounds in advance. ...