1. Choose a theme: First, determine the theme of the math comic book to be drawn. This can be specific concepts in textbooks, such as fractions, geometry, time, etc. Or a mathematical story, such as the story of a mathematician, the application of mathematics in daily life, etc.

2. Design the plot: Design the plot of the cartoon according to the theme. This can be a continuous story or several related scenes.

3. Sketch: Draw a sketch before starting formal drawing. This can help plan the location and size of each scene, as well as the layout of people and objects.

4. Formal drawing: Use colored pens or pigments to formally draw cartoons according to sketches. Pay attention to the collocation of details and colors to make the picture more vivid and attractive.

5. Add subtitles: Add subtitles next to or below each scene to explain the mathematical concepts and plots in the picture.