With the gradual popularization of high school education, there are more and more students with learning difficulties in various schools, especially in mathematics. Even the students' talk about numbers has become pale and powerless, and mathematics has become their "stubborn disease". Effectively transforming students with learning difficulties is an important link for schools to realize quality education, and it is also a key research topic for school education and teaching. To explore the transformation of students with learning difficulties, we must analyze the causes of students with learning difficulties and find out the methods and measures of transformation on this basis. This paper discusses the transformation of students with learning difficulties in senior high school mathematics teaching. Talk about some of my own views and opinions.