In the first few years, Google's prediction was relatively accurate, but later it lost its accuracy. The project was terminated on 20 15. The reason why Google failed to predict the flu is that it only relies on the keywords of search engines and ignores the data from other sources. What are the analysis algorithms and mathematical models of Internet of Things data? It is understood that many people lament that big data analysis has no hope. But in fact, big data analysis and artificial intelligence application innovation, security and iot services have not been developed. The influenza prediction research group set up by the US Centers for Disease Control and Prevention can grasp the active trend of influenza one week in advance by using massive data and the artificial intelligence algorithm model of Ping An Technology, so as to carry out effective prevention and control.