Causes of high uric acid
1, eat more high purine food.
Long-term consumption or one-time consumption often leads to more uric acid, which can not be excreted in time, leading to an increase in uric acid in the body.
2. Excessive endogenous purine production.
Metabolic disorder of purines in the body. Excessive endogenous purine production is far more important than excessive purine intake in food, which is an important factor leading to uric acid is too high.
3, uric acid excretion function decreased.
The decrease of uric acid excretion function is a pathological phenomenon of hyperuricemia, and the decrease of renal function leads to the decrease of excretion function, which leads to the increase of uric acid value.
4. Disease
Hypertension, hyperlipidemia, obesity, hematological diseases, tumors and other diseases can also easily lead to the increase of uric acid.
What are the symptoms of high uric acid?
Hyperuricemia has different symptoms at different stages.
1, asymptomatic hyperuricemia
Blood tests showed that the serum uric acid concentration increased, but there were no clinical symptoms such as arthritis, hyperuricemia stones and kidney calculi. This period is generally not easy to detect unless it is tested. Asymptomatic hyperuricemia can last 10 ~ 20 years, and some of them can be hyperuricemia-free for life. Generally speaking, the higher the blood uric acid level, the greater the risk of high uric acid.
2. Acute hyperuricemic arthritis
Local joint injury, overeating, excessive fatigue, cold and dampness, certain drugs, infection and surgery can all induce acute attacks. These factors can make the supersaturated uric acid form needle-like crystals and deposit in synovial fluid. The lens is regarded as alien by white blood cells in the body, swallowed up and released inflammatory factors, causing acute attacks.
3. Gouty arthritis
In particular, acute characteristic arthritis and chronic tophi diseases mainly include acute paroxysmal arthritis, tophi formation, tophi chronic arthritis, uric acid nephropathy and uric acid urinary calculi, and in severe cases, joint disability and renal insufficiency may occur. Gout is often accompanied by abdominal obesity, hyperlipidemia, hypertension, type 2 diabetes and cardiovascular diseases.
Common attack sites are thumb joint, heel, ankle joint and knee joint. Some patients with long-term gout attack have soft tissues in their finger joints and even in their auricles. Acute gout attacks, characterized by redness, swelling, fever and severe pain, usually occur at midnight, which can wake people up from sleep.
Diet alone cannot effectively reduce uric acid.
80% of uric acid in human blood comes from purine metabolism, and only 20% comes from food intake. Therefore, the effect of simple diet control on reducing serum uric acid level is very limited, and it is necessary to choose reasonable drugs (allopurinol, febuxostat or benzbromarone) to reduce uric acid according to the condition.
Many patients refuse to take medicine for fear of "side effects", which is a typical food choking cough. As long as drugs are used scientifically and regularly, the risk of rare complications of drugs is not higher than that of going out to encounter a car accident. Who stays at home all day for fear of a car accident?
To reduce uric acid, drugs alone are not enough.
Some patients think that they can rest easy and eat as much as they want after applying uric acid-lowering drugs. This idea is not only wrong, but also dangerous.
For chronic metabolic diseases such as gout, low purine diet is the premise and basis of treatment. Without reducing purine intake from the source, it is difficult to control the disease by drugs alone. However, due to overeating, uric acid is obviously increased, so it is necessary to increase the dosage of the drug, which will also increase the risk of adverse drug reactions.
How does high uric acid come down?
Hyperuricemia is a metabolic disease caused by purine metabolism disorder in human body, which leads to the increase of uric acid in blood. It is very easy to cause gout and other diseases, so how to reduce the high uric acid?
1, uric acid reducing drugs
When high uric acid causes gout and other diseases, drugs are needed to reduce uric acid. Uric acid-lowering drugs mainly reduce uric acid by promoting uric acid excretion and inhibiting uric acid synthesis. However, drugs that reduce uric acid generally have side effects and are harmful to the body. Don't take it without permission unless the doctor asks.
Step 2 drink plenty of water
Patients with high uric acid should drink more boiled water or light tea. Drinking more water can increase the urine volume of the body, promote uric acid excretion with urine, and achieve the purpose of reducing uric acid. It is generally recommended that the daily urine output of patients with high uric acid should be controlled at around 3000ml. You can also use diuretic tea and barley porridge to reduce uric acid, and drink less hot drinks.
3. Control purine intake
Try to choose foods with low purine content, and the daily intake of purine should not exceed 300 mg. Low-purine foods include rice, corn, eggs, milk and various fruits and vegetables.
Eat less or not eat high-purity foods such as meat, fish, seafood, animal offal and bean products. It is suggested that the purine content of various common foods should be specially recorded to restrain the desire to eat.
Step 4 control calorie intake
Avoid eating too many calories. It is advisable to maintain the ideal weight. Obese or overweight people should reduce calorie intake and lose weight as soon as possible. Generally obese people are prone to diseases such as hyperlipidemia, which will hinder the excretion of uric acid.
Step 5 quit smoking and drinking
Patients with high uric acid also need to quit smoking and drinking, and alcohol and tobacco will lead to an increase in uric acid. In particular, patients with high uric acid should be forbidden to drink beer. Beer contains more guanylic acid, which will produce purine after metabolism in human body, and eventually form uric acid, which will lead to the increase of uric acid. Moreover, beer contains ethanol, which can promote the synthesis of lactic acid. When lactic acid and uric acid are excreted from the kidney, they will compete with each other, so that the increase of lactic acid will reduce the excretion of blood uric acid, which will lead to the increase of blood uric acid. Ethanol can also promote the synthesis of purine and increase the output of uric acid.
6. What can I eat to reduce uric acid?
Avoid foods with high purine content;
Animal viscera (liver, intestine, kidney and brain), seafood (abalone, crab, lobster, octopus, sardine, tuna, carp, bass, trout and cod), shellfish, meat (cattle, sheep, ducks, geese and pigeons), legumes, lentils, spinach and cauliflower.
Avoid eating foods with high cholesterol;
Animal viscera (liver, intestine, kidney and brain), fat meat, squid, fish and cuttlefish.
Abstinence from alcohol:
Do not drink alcohol, especially beer and Shaoxing wine.
Once the alcohol concentration in blood is as high as 200mg/dl, lactic acid in blood will increase with the oxidation process of alcohol, which will hinder the excretion of uric acid in kidney and increase uric acid in blood as a result.
Avoid eating acidic foods such as coffee.