Guangzhou Zhiyong Middle School takes the word "Zhiyong" as its school name. The aim of running a school is: "Induce first, then seek knowledge, then deduce and apply, and pay equal attention to both knowledge and application", thus forming the school-running concept of "seeking knowledge and applying". Famous scholars and revolutionaries such as Lu Xun, Mao Dun, Ou Yangyuqian, Liao Chengzhi, Xia Yan and Zuo Jin. Used for lectures. Famous writers Ouyang Shan, Wu Youheng and world women's diving champion Chen are all graduates of Zhisong Middle School. 1956, the school turned into a public school; From 65438 to 0982, Zhiyi Middle School became the first school in Guangzhou to implement the principal responsibility system, and the school developed more rapidly.

In 2000, the school was rated as a first-class school in Guangdong Province, an excellent high school in Guangdong Province, a green school in Guangdong Province, an experimental school of modern educational technology in Guangdong Province, and a national advanced unit in educational and scientific research experiments of the Central Academy of Educational Sciences. The school is now a complete middle school with 38 classes, covering an area of 16400 square meters. Teaching building, science building, library, laboratory, sports ground, biological park, geographical park, campus network and other equipment and facilities are fully equipped according to provincial school standards. Multimedia teaching platform has entered the classroom, and good school conditions have laid the foundation for the further development of the school. In 2003, Zhiyong Middle School merged with Guangzhou No.99 Middle School, expanding the scale of running a school. The former Guangzhou No.99 Middle School became the junior middle school of Zhiyong Middle School (West Campus). In August 2009, junior high school moved to No.468, Jiefang Middle Road (the former site of No.34 Middle School).