Since the mid-1970s, according to the theory and clinical experience of traditional Chinese medicine, the research on prevention and treatment of liver cirrhosis and anti-hepatic fibrosis with traditional Chinese medicine has been carried out. So far, research shows that Chinese medicine has obvious advantages in treating liver fibrosis.

1. Qianggan Ruanjian Decoction (Han Jinghuan, 1979) has the functions of invigorating qi and spleen, promoting diuresis and nourishing yin, promoting blood circulation and resolving hard mass. Comprise radix astragali, rhizoma Atractylodis Macrocephalae, Poria, radix rehmanniae, radix Paeoniae alba, radix Salviae Miltiorrhizae, radix Angelicae sinensis, radix Curcumae, cortex moutan, fructus Gardeniae, carapax Trionycis, herba Artemisiae Scopariae, etc. The rat model of liver cirrhosis was established by intraperitoneal injection of carbon tetrachloride, and the experimental study was carried out by autologous liver biopsy for 3 years. After long-term treatment, the inherent morphological characteristics of liver cirrhosis have disappeared. However, the animals in the control group recovered to some extent after stopping the injection of carbon tetrachloride 1 year, but they tended to deteriorate in the future, and they still showed the pathological characteristics of cirrhosis until two and a half years later.

2. Compound 86 1 (also known as Compound Danshen Mixture, Wang Baoen, etc. ) is composed of Radix Astragali, Radix Salviae Miltiorrhizae, Caulis Spatholobi, etc. 10. In the clinical treatment of chronic hepatitis B patients with hepatic fibrosis, 49 patients insisted on taking medicine for more than half a year. After treatment, the improvement rate of symptoms was 67%, and the contents of serum P-ⅲ-P and laminin were significantly lower than before treatment. The recovery rate of ALT activity was 73%, the diameter of portal vein decreased in 33% patients, and the retraction rate of splenomegaly was 52%. The granules made from this prescription are used to treat chronic hepatitis B, each time 1 bag (including 8 grams of crude drugs), once a day 1 time, for a total of 6 months. 12 cases had two liver biopsies before and after treatment, and the liver histological inflammation score changed from 18 before treatment. 25 2? 07 to 8 after treatment? 5 2? 7, fibrosis score from 10? 0 9? 92 down to 2? 98 2? 07; But there was no change in the control group before and after treatment. Before treatment, there were many myofibroblasts in the inflammatory area of liver tissue, and a-SMA staining was positive, which decreased significantly after treatment.