In short, space disinfection in clean area refers to the disinfection of all exposed object surfaces and space air in clean area by using the technology of killing microorganisms. With the new version of GMP promoting space disinfection, it has become a key link in pharmaceutical factory verification and one of the important items identified by inspection. According to incomplete statistics, at present, most pharmaceutical factories use traditional sterilization technology, but with the rapid development of science and technology, especially the update of pharmaceutical technology, the disadvantages of traditional sterilization methods are increasingly exposed, which is difficult to meet the requirements of enterprises themselves and related laws and regulations. While seeking disinfection technology with excellent sterilization effect and saving economic cost, pharmaceutical companies are also considering occupational health and safety factors.

We are well aware that we need to ensure that every investment you make can run smoothly for many years, and at the same time, we must meet the high standards of cleanliness and hygiene and regulatory requirements in order to achieve sustained success. The environmental quality of pharmaceutical workshop will definitely achieve the best effect in daily work. In foreign countries, silver hydrogen peroxide compound disinfectant is used in clean room GMP purification workshop to achieve the purpose of effective GMP purification workshop sterilization. Silver hydrogen peroxide compound disinfectant can effectively remove microorganisms in GMP purification workshop, including spores, bacterial spores, fungal spores, radioactive bacteria, mycobacteria, yeasts, molds and viruses. Ensure the cleanness of the dust-free workshop.

At present, the disinfectants used in pharmaceutical factories mainly include the following:

75% alcohol

Intermediate disinfectant is easy to produce drug-resistant bacteria, can only inhibit spores, can not kill spores, has low toxicity and no residue, and substances soluble in alcohols are incompatible.

quaternary ammonium salt

The recognized disinfectant with low efficiency is easy to produce drug-resistant bacteria and cannot kill gram-negative bacteria. Disinfectants themselves are easily contaminated by microorganisms. Can not kill spores, there are residues, which are obviously corrosive to aluminum products.

Phenol/coal phenol soap

The intermediate disinfectant is corrosive, difficult to degrade and harmful to the environment. Can't kill spores. A/B clean area should be used, disinfected and filtered.

These three disinfectants are all traditional, but as can be seen from the above analysis, they are not ideal to use. The new GMP requires pharmaceutical companies to use more than two kinds of disinfection products, so it is not necessary to abandon the traditional disinfection products directly, and it can be used alternately with new disinfectants.

Silver hydrogen peroxide compound disinfectant is a kind of disinfection products which has a huge gap with traditional products. The oxidant used is peroxide, which combines with stabilizer to form a composite solution. Trace silver ions added as catalysts can maintain long-term effectiveness. The bactericidal effect of silver ions is based on the strong combination of monovalent silver ions with bacterial proteins through valence bonds and coordination bonds, thus inactivating or precipitating bacteria. Features: It can quickly kill all kinds of microorganisms including spores, bacterial spores, fungal spores, radioactive bacteria, mycobacteria, yeasts, molds and viruses. And is colorless, odorless, non-toxic and residue-free, and does not produce any side effects. It can be used in GMP workshop, clean workshop, cosmetics, health products purification workshop, food and beverage industry (including CIP sterilization and cleaning), electronic products, semiconductors, optoelectronics, precision manufacturing, bioengineering, aerospace and other industries. Compared with chlorine preparation, bromine preparation and aldehyde disinfectant, it has higher safety, stronger spore killing ability and safer ability to human body.

Octavian D50

The main component is silver peroxide ion. Imported from Germany, it is a food-grade fungicide with high efficiency and broad spectrum. It has the characteristics of thorough sterilization, no microbial resistance, no toxic residue and no repeated pollution, and has been widely used in the pharmaceutical industry. In the pharmaceutical industry, Octavius D50 is an excellent disinfection products, which has been accepted by major regulatory agencies. If necessary, a complete material compatibility guide can be provided. Octavium D50 has been proved to have broad-spectrum bactericidal effect on many microorganisms affecting pharmaceutical industry. In the pharmaceutical industry, a clean biological environment is very important, and Octavius D50 has more obvious advantages than other disinfection products. Traditional disinfection methods and disinfectants, such as sporicides, not only take a long time, but also are very dangerous to people. The emergence of Ming Rui is undoubtedly your best choice, creating greater value for your investment and production. The disinfection process of Octex D50 is rapid, residue-free and safe, and the products produced are only water and oxygen. It has a wide range of material adaptability, which means that the risk of damage to buildings is very small, and it can be used as a spore killer product in a fixed pharmaceutical factory.

Advantages of Octavian:

① Efficient disinfection and sterilization ability: Octavie belongs to a broad-spectrum disinfectant, which can kill more than 200 kinds of harmful bacteria, microorganisms, spores and viruses, including mold, Escherichia coli and salmonella, and can completely kill all kinds of bacteria encountered in GMP workshops.

② Good stability: Octex is a multi-component composite solution with good stability. It can remain stable at high temperature, and even at high temperature, its utility will be enhanced. Not affected by temperature, light and PH value. The processing technology of GMP workshop is complex, which leads to frequent changes of temperature and PH value in the production process. Therefore, Ming Rui's high stability and adaptability are particularly suitable for GMP, and Ming Rui will not change the PH value and other parameters of the product, so it is unnecessary to add other auxiliary products.

③ No drug resistance: Unlike chlorine dioxide, antibiotics and other products, Octavius' unique sterilization principle will not produce drug resistance, which can achieve the following two purposes: after using Octavius disinfectant, there will be no additional sterilization products.

After a period of use, the effect of traditional sterilization and anti-corrosion products will gradually decline until they fail. Ming Rui is a product that will not produce any drug resistance, so it can be used in GMP production stably for a long time.

(4) Ecological disinfection and sterilization products in the true sense: The main component of Okta Weiss is hydrogen peroxide, which is decomposed into oxygen and water after the action, and will not produce any harmful residues on the products. Octavius has been used in pharmaceutical, food processing, drinking water, beverage, dairy products processing and other industries around the world.

⑤ Trace silver ions in alum have long-term efficacy and antibacterial function, which can ensure the long shelf life of the product.

Specific application and proportion of Ming Rui D50;

Environmental disinfection:

After diluted with 3% concentration, it is sprayed on the whole environment with the dosage of 10-20ml/m3. Seal for 60-120min after spraying.

Disinfection of equipment surface:

After diluted with 3% concentration, spray or wipe evenly. The dose was 100ml/m2. Small utensils and accessories can be directly soaked in 3% diluent for at least 30 minutes (the best effect is 4 hours).

Sporicides:

Spray or wipe after 3% dilution. Increasing the concentration can effectively shorten the action time, and it can be used as an efficient spore killing agent after being diluted at the concentration of 15%, which can quickly kill spores and spores and spray or wipe the surface. The action time is 5 minutes.

Water disinfection:

Disinfection of process water, washing water and circulating water: 30ppm. Pipeline impact cleaning: 1‰, pipeline maintenance: 30ppm.

Washing clothes and washing hands:

Dilute 3% concentration before use.

Jinan chenyu environmental protection technology co., ltd is a high-tech company involved in new chemical materials. Committed to the application of new chemical materials in industry, agriculture, life, water treatment and other fields, improve the efficiency of industrial and agricultural production, improve the quality of human life, save water resources and reduce the discharge of harmful substances. Provide a series of solutions for industrial and agricultural production enterprises to encounter microbial hazards in the production process.