Medical field
In this paper, the research status of various long-chain unsaturated fatty acids with edible and health value in algae is emphatically introduced.
Lipids and lipid metabolism in eukaryotic algae
Authors: Guschina, I.A. Harwood, J.L.
Journal full name: lipid research progress
Year, volume (period): page number: Volume 45, No.2, 2006 160- 186.
English abstract:
Eukaryotic algae is a very diverse biological group, which inhabits a wide range of ecosystems from Antarctica to desert. They account for more than half of the primary productivity at the bottom of the food chain. In recent years, the research on lipid biochemistry of algae has shifted from the experiment of a few model organisms to include a large number of usually uncommon algae. This led to the discovery of new compounds, including the main membrane components and the elucidation of lipid signaling pathways. One of the main driving forces of recent research is to try to find genes encoding various protein expressions, which are involved in the production of very long-chain polyunsaturated fatty acids such as arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid. This paper describes such work and how environmental factors, such as light, temperature or minerals, change the lipid metabolism of algae and adapt to possible information.
Chinese translation:
Research progress of lipid and its metabolism in eukaryotic algae
Eukaryotic algae is a diverse population, covering a wide range, and its habitat covers various ecosystems from Antarctic circle to desert. Algae account for more than half of primary productivity and become the basis of food chain. In recent years, the biochemical research on lipids in algae cells has been extended from a few model microorganisms to other species, and many species have been studied, including some uncommon algae. These studies have led to the discovery of many new compounds, including some major components of cell membrane and important molecules in lipid signal transduction pathway. The main goal of these studies is to find the coding genes of these long-chain unsaturated fatty acid synthetic proteins. At the same time, this paper also summarizes the effects of environmental factors (such as light, temperature and trace elements) on lipid metabolism of algae and the related research information of algae cell response mechanism.
Impact Factor (2005) 8.438+00
-
Full-text connection
And lipid metabolism in eukaryotic algae.
-
Full Text Connection -2
And lipid metabolism in eukaryotic algae.part2.rar (106.03k).
-
* * * Five articles were translated, including three summaries and two research articles. They are all related to marine drugs, most of which are marine anticancer drugs. I have tried my best to translate some words. If I can't find the Chinese translation name, there will be no translation.
Personally, I think the level of Article 4 is very high. At this time, articles published in PNAS, general chemistry articles and JACS (about impact factor 7) are top magazines. What we do is to determine the configuration and conformation of marine complex natural products. The compound is a macrolide with the side chain of 25 yuan's ring belt. Similar to anemone toxin, the research method is to determine its three-dimensional structure step by step from the structural fragments. Of course, the structure studied in this paper is not as complex as anemone toxin (1polyether compound with 29 carbon atoms, molecular weight 2677, containing 40 hydroxyl groups and 8 methyl groups). Although the three-dimensional structure of the whole structure has not been determined in this paper, the research in this paper laid the foundation for determining the three-dimensional structure of this kind of compounds.
The first article (article type: summary)
Title: Marine Pharmacology in 2003-2004: Antitumor and Cytotoxic Compounds.
Authors: Alejandro Meyer, Kirk gustafson,
Full name of the magazine: European Journal of Cancer (if for 2005:3.706；; If 2005: 3.302)
Year, Volume (Issue): Page number: 42 (2006): 224 1-2270.
Abstract: During 2003 and 2004, marine pharmacological research aimed at discovering and developing new anticancer drugs was published in 163 peer-reviewed article. The purpose of this review is to evaluate the antitumor and cytotoxic properties of 150 marine natural products, many of which are new compounds belonging to different structural categories, including polyketones, terpenes, steroids and peptides. Organisms that produce these bioactive marine compounds include invertebrates, algae, fungi and bacteria. The anti-tumor pharmacology of 3 1 marine natural products with clear structure was studied, and their mechanism of action was further determined in a large number of experiments and clinical models. It is reported that in vitro cytotoxicity data generated by mouse and human tumor cell lines are particularly effective for 1 19 new marine chemicals, but the mechanism of action has not yet been determined. It is worth noting that marine anti-cancer research is supported by global cooperation, with participants including researchers from Australia, Austria, Canada, China, Egypt, France, Germany, Italy, Japan, Mexico, Netherlands, New Zealand, Papua New Guinea, Philippines, South Africa, South Korea, Spain, Switzerland, Taiwan Province, Thailand and the United States. Finally, this literature review of marine pharmacology in 2003-2004 emphasizes the fact that the discovery of new marine antitumor drugs was at the same speed as that in 1998-2002.
Chinese translation (including theme):
Marine Pharmacology in 2003-2004: Antitumor and Cytotoxic Compounds
In 2003-2004, he published papers on marine pharmacology 163, and his research direction was to find new anti-tumor drugs. The purpose of this review is to analyze the chemical structures of about 150 marine natural products, many of which belong to different structural types, including polyketones, adhesives, steroids and peptides. Organisms that produce these active compounds include invertebrates, algae, fungi and bacteria. On a large number of experimental and clinical models, the researchers studied the anti-tumor pharmacology of 3 1 marine natural products with clear structure, and further clarified its mechanism of action. It is reported that * * * there are 1 19 new marine compounds with particularly strong cytotoxicity to mouse or human tumor cells in vitro, and the mechanism of action has not been clarified. It is worth noting that many countries around the world have cooperated in the research of marine antitumor drugs, including Australia, Austria, Canada, Egypt, France, Germany, Italy, Japan, Mexico, the Netherlands, New Zealand, New Guinea, the Philippines, South Africa, South Korea, Spain, Switzerland, Taiwan Province Province, Thailand and the United States. Finally, the review of marine pharmacological research in 2003-2004 shows that the speed of discovering new antitumor compounds is the same as that in 1998-2002.
The second article (article type: summary)
Indole Arabian marine natural products: a recognized source of cancer drugs, which is expected to be used to control mental, neurological and other diseases.
Authors: Wasim Gul, Mark T. Harman,
Full name of the magazine: Life Science (if it is 2005: 2.512; If 2005: 2. 158)
Year, Volume (Issue): Page number: 78 (2005): 442-453.
Abstract: Marine environment produces natural products from a variety of structural categories, which show activity against quantitative disease targets. History. Marine natural products have been widely used as anticancer agents. Indole alkaloids are a kind of marine natural products, which show unique prospects in the development of new drugs. This report reviews the literature of indole alkaloids from marine sources and also emphasizes our own research. The special biological activities of indole alkaloids include cytotoxicity, antivirus, antiparasitic, anti-inflammatory, serotonin antagonism, calcium release, calmodulin antagonism and other pharmacological activities.
Chinese translation (including theme):
Indole alkaloid marine natural products: a clear library of anticancer drug lead compounds, have good prospects in the treatment of parasitic diseases, neuropathy and other diseases.
The ocean produces a large number of natural products with various structural types, which act on different disease targets. The research on marine natural products in history is mostly in the direction of anti-cancer. Indole alkaloids in the ocean have unique good prospects as lead compounds of new drugs. This paper summarizes the literature about indole alkaloids from marine sources, including our own research. Here, we show the unique biological activities of indole alkaloids, including cytotoxicity, antivirus, antiparasitic, anti-inflammatory, antagonistic 5- hydroxytryptamine, calcium release, antagonistic calmodulin and other pharmacological activities.
The third article (article type: summary)
Topic: Marine natural products as anticancer drugs.
Authors: T. Luke Simmons, Eric Andriana Solo, Kerry McPhail, Patricia Flatt and William H. Gerwick.
Full name of the journal: Molecular Cancer Therapeutics (if for 2005: 5.171; If it was 5.242 in 2004)
Year, volume (issue): page number: 2005; 4(2):333–42
Abstract: The chemical and biological diversity of marine environment is immune, and there are strange resources for finding ne. Anticancer drugs. Recent technical and methodological advances in structural elucidation, organic synthesis and bioassay have led to the separation and clinical evaluation of various new anticancer agents. The structural types of these compounds range from simple linear peptides, such as dorastatin 10, to complex macrocyclic polyethers, such as spongosine b; Equally diverse is the molecular action mode that these molecules give them biological activity. This review focuses on several marine natural products and their synthetic derivatives, and the anticancer drugs currently undergoing clinical evaluation.
Chinese translation (including theme):
Marine natural products as anti-tumor drugs
The chemical and biological diversity of the marine environment is immeasurable, so the ocean is a special resource for discovering new anticancer drugs. In recent years, the development of structure identification, organic synthesis and bioanalysis in technology and methodology has led to the separation and clinical evaluation of various new anticancer drugs. These compounds have different structures, ranging from simple linear peptides (such as dorastatin 10) to complex macrocyclic polyether compounds (such as spongosine b). Just like the structural differences, the molecular modes of transfer of these compounds are also different. This paper reviews some marine natural products and their synthetic derivatives. At present, these compounds are being clinically evaluated as anticancer drugs.
The fourth article (article type: research article)
Synthesis of antibacterial marine macrolides: synthesis and configuration distribution of C5-c 16 degradation fragment of Reidispongioride A.
Authors: Ian Patterson, Robert Britten, Kate Ashton, Hannah Knus and Jonathan Stafford.
Journal of the National Academy of Sciences.
Year, volume (issue): page number: August 200417; 10 1(33): 1 1986– 1 199 1.
Abstract: Reidispongioride a is a representative member of the sphingosine lactone/reidispongiolide group of cytotoxic 26 yuan macrolides from marine sources. By interacting with actin in cytoskeleton, reidispongiolides and sphinxolides are effective microfilament destabilizers, which represent a promising mechanism for developing new anticancer drugs. The aldol-based synthesis of C8–C16 and C5–C16 diastereomer libraries, and the detailed NMR comparison with the reported degradation fragments, realized the configuration distribution of the main part of the reidispongiolide macrocycle core, thus laying a solid foundation for the ongoing synthesis work.
Chinese translation (including theme):
Synthesis of marine macrolides with anti-microfilament activity: synthesis and conformation design of decomposition fragment C5–C16 of Reidispongioride A.
Reidispongiolide A is the representative of 26 yuan macrolide with sphingosine lactone/reidispongioride group from the ocean. By interacting with actin in cytoskeleton, these macrolides make microfilaments unstable, which is a promising mechanism for developing new anticancer drugs. Using butyraldehyde as the starting material, the diastereomer libraries of C8-C 16 and C5-C 16 were synthesized, and their NMR data were compared with the reported decomposition fragments in detail, thus the conformation of the main part of the macrocyclic mother nucleus of rediponelactone was determined, which laid a solid foundation for the subsequent synthesis.
The fifth article (article type: research article)
Title: Crown lactam, a new 22-atom macrocyclic lactam from marine actinomycete Streptomyces Crown.
Authors: Scott S. Mitchell, Benjamin Nicholson, Syteisan, Kin S. Lam and Barbara C.M. Potts.
Journal of Natural Products (2005: 2.202; If it was 2.267 in 2004)
Year, Volume (Issue): Page number: August 2004; 67: 1400-2.
Abstract: In the process of screening new anticancer and anti-infective agents from marine microorganisms, we found that Streptomyces aureofaciens (NPS00 1583) isolated from marine sediments produced a new macrolactam with cytotoxicity to various tumor cell lines. Using extensive MS, UV and NMR spectral analysis, its structure has been identified as compound 1, aureoverticillactam, a 22-atom macrocyclic lactam containing triene and tetraene conjugated olefins.
Chinese translation (including theme):
22 yuan macrolactam Aureoverticillactam produced by marine actinomycete aureoverticillatus.
In the process of trying to screen new anticancer drugs from marine microorganisms, we found that Aureoverticillatus (NPS 001583), an actinomycete of Streptomyces isolated from marine sediments, can produce a new macrolactam, which has cytotoxic effect on several different tumor cells. The structure of compound 1 (acacia lactam) was confirmed by various spectral analysis including mass spectrometry, ultraviolet and nuclear magnetic resonance. It is a 22 yuan ring macrolactam containing * * * conjugated trienes and * * * conjugated tetraenes.
If your English level is good, you can go directly to www.uspto.gov.
PPT version of foreign literature information retrieval (including foreign book information retrieval, foreign periodical paper retrieval, foreign newspaper retrieval), please contact me if necessary.