Microscopically, we can see that the endometrial glands have different shapes and sizes, and the number is increasing. Some glands are very small, and some glands are cystic, which is called adenocystic hyperplasia? Glandular epithelial cells are high columnar, pseudo-stratified or stratified? In some enlarged glands, glandular epithelial cells can become low columnar due to compression? Interstitial cells between glands also proliferate and mitosis is common? Proliferated endometrial glands and stroma generally have no secretory changes?

A few of them are mainly glandular hyperplasia, interstitial hyperplasia is even unabated, and the hyperplastic glands are closely arranged, which can be called adenomatous hyperplasia? Adenoepithelial hyperplasia, protruding into the cavity, and even forming a solid cell mass?

In some cases of endometrial hyperplasia, the proliferating glandular epithelial cells have large nuclei, dark staining and irregular arrangement, showing atypical hyperplasia. This lesion tends to become cancerous, and it is generally believed that it can eventually develop into uterine body cancer?

Clinically, because a large amount of estrogen makes the endometrium proliferate too long, will patients have irregular uterine bleeding, and often a lot of bleeding? Irregular and persistent bleeding can also occur after amenorrhea for a period of time. Patients often suffer from anemia due to excessive blood loss. In addition, because of ovarian dysfunction, there is no egg discharge, so it is impossible to conceive at this stage?